Radiotherapy enhances innate and adaptive antitumor immunity; however, the effects of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor microenvironment (TME) are not fully elucidated. Although previous reports suggest an increased...
Sydney Vital, a translational cancer research centre funded by the Cancer Institute New South Wales (CINSW) and the University of Sydney, is the first centre in Australia to acquire an Xstrahl Small Animal Radiation Research Platform (SARRP). Sydney Vital’s aim is to...
High-precision radiotherapy requires precise positioning, particularly with high single doses. Fiducial markers in combination with onboard imaging are excellent tools to support this. In the study “BioXmark for high-precision radiotherapy in an orthotopic pancreatic...
The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with...
The UK SARRP user group workshop is fast approaching but you still have a good chance to register to attend and find out the latest developments in the area of pre-clinical research. The event is taking place on Wednesday June 27th following the 2018 ARR meeting at...
In recent years, small animal image-guided irradiators have been widely utilized in preclinical studies involving rodent models. However, the dosimetry commissioning of such equipment involving kilovoltage small-field dosimetry has not received as much interest as the...
BACKGROUND: Recently, imaging and high-precision irradiation devices for preclinical tumor models have been developed. Image-guided radiation therapy (IGRT) including innovative treatment planning techniques comparable to patient treatment can be achieved in a...
Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. The Xstrahl small animal radiation research platform (SARRP) enables state-of-the-art...
For the last 12 years the CIX3 irradiator cabinet has been a stable of cancer research centres around the world. With demand high, Xstrahl spent 2 years developing a new generation of the system, with reduced footprint, safer controls, larger irradiation chamber and...
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