BACKGROUND AND PURPOSE: Patients with malignant pleural mesothelioma (MPM), who undergo chest instrumentation, may develop seeding at the site of intervention, leading to subcutaneous tumour. This is believed to be reduced by the common practice of prophylactic...
BACKGROUND: Keloids have been treated by using radiation for over a century, and it is currently suggested that keloids are best treated by a combination of surgery and postoperative radiation therapy, although randomized controlled trials testing this are still...
OBJECTIVES/HYPOTHESIS: To discuss the role of radiotherapy (RT) in the treatment of cutaneous squamous and basal cell carcinomas of the head and neck. METHODS: Review of the pertinent literature. RESULTS: The likelihood of cure with a good cosmetic outcome is high for...
Patients treated with palliative intent present a complex issue for radiotherapy departments in terms of their specific care needs, treatment times, and the productivity of orthovoltage resources. This study seeks to evaluate and quantify patient-related factors,...
In this article, the management of cutaneous T-cell lymphoma will be presented in terms of the strategies that guide treatment. With the strategies and goals in mind, treatment options to achieve a measurable goal will be presented. The treatments presented in this...
PURPOSE: To show radiation dose-response relationships for recurrence of keloid and pterygium after radiotherapy following surgery. METHODS AND MATERIALS: Using PubMed, we performed a retrospective review of articles reporting incidences and/or dose-response...
Despite the emphasis on megavoltage radiation therapy, kV units are still being acquired and used in clinical radiation therapy for superficial lesions and specialized treatment techniques. The dosimetry of kV X-ray beams is tricky and subject to increased...
We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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BACKGROUND: A lot of retrospective data concerning the effect of radiotherapy on the painful heel spur (plantar fasciitis) is available in the literature. Nevertheless, a randomized proof of this effect is still missing. Thus, the GCGBD (German cooperative group on...
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