High-dose rate electronic brachytherapy (EBT) using surface applicators allows for convenient hypofractionated treatment of non-melanoma skin cancer (NMSC). However, EBT delivers a higher surface dose as compared to commonly used superficial x-ray or electron...
Treatment of non-melanoma skin cancers (NMSC) in cosmetically sensitive locations can be challenging. Methods of treatment include different modalities of RT (orthovoltage x-rays, electron-beam RT, high-dose rate [HDR] brachytherapy) and surgical excision, all of...
The immune infiltrate in colorectal cancer has been correlated with outcome, such that individuals with higher infiltrations of T cells have increased survival independent of the disease stage. For patients with lower immune infiltrates, overall survival is limited....
PURPOSE: This dissertation focuses on establishment of pre-clinical methods facilitating the use of PET imaging for selective sub-volume dose escalation. Specifically the problems addressed are 1.) The difficulties associated with comparing multiple PET images, 2.)...
Cancer radiotherapy is often complicated by a spectrum of changes in the neighboring bone from mild osteopenia to osteoradionecrosis. We previously reported that parathyroid hormone (PTH, 1–34), an anabolic agent for osteoporosis, reversed bone structural...
An important characteristic of kilovoltage therapy is the narrow penumbra obtainable with a well designed collimator system. A graphical illustration of applicator geometry is used to show that undesirable penumbral broadening and consequent reduction of field...
BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adults and is associated with a poor prognosis. Cytotoxic T lymphocyte antigen -4 (CTLA-4) blocking antibodies have demonstrated an ability to generate robust antitumor immune responses against...
The technical evolution of radiation therapy for brain cancer has improved both the efficacy of individual radiation treatments and patient safety. The advent of computed tomography (CT)-based planning marked an important initial shift toward target-directed treatment (1). Treatment planning accuracy was further increased by fusing CT planning images with positron emission tomography (PET) and magnetic resonance imaging (MRI) scans (2, 3). Additionally, cone beam CT images acquired before each fraction were added to compensate for any deviations from the simulation CT (4).
Joshua T. Dilworth, Sarah A. Krueger, George D. Wilson, Brian Marples
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OBJECTIVES: To determine whether poly (ADP-ribose) polymerase-1/2 (PARP-1/2) inhibition enhances radiation-induced cytotoxicity of pancreatic adenocarcinoma in vitro and in vivo, and the mechanism by which this occurs. METHODS: Pancreatic carcinoma cells were treated...
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