Poor survival rates of patients with tumors arising from or disseminating into the brain are attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier (BBB) penetration of chemotherapies/targeted agents, and an intrinsic tumor...
PURPOSE: The goal of this work was to develop and test a cylindrical tissue-equivalent quality assurance (QA) phantom for micro computed tomography (microCT) image-guided small animal irradiators that overcomes deficiencies of existing phantoms due to its mouse-like...
Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could better leverage these effects in clinical translation. This study...
April 24th, 2019 New 150kV superficial treatment system and SARRP research platform among advanced solutions showcased on Xstrahl booth (No. 3420) at European Society for Radiotherapy & Oncology annual meeting in Milan, April 26th-29th Xstrahl Medical, global...
The extent of tumor oxygenation is an important factor contributing to the efficacy of radiation therapy. Several preclinical studies have shown benefit of combining radiation therapy with drugs that inhibit tumor blood vessel growth, i.e. angiostatic therapy. Recent...
Current treatment methods for arteriovenous malformation (AVM) are surgery and radiosurgery. However, complete occlusion post radiosurgery is achieved within 3 years, while patient remain at risk of haemorrhage. Therefore is important to develop a new molecular...
Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in the regulation of CD8+...
The radiopharmaceutical (131)I-meta-iodobenzylguanidine ((131)I-MIBG) is an effective treatment for neuroblastoma. However, maximal therapeutic benefit from (131)I-MIBG is likely to be obtained by its combination with chemotherapy. In a previous paper by Nile DL, Rae...
The main objective of radiobiology is to establish links between doses and radiation-induced biological effects. In this context, well-defined dosimetry protocols are crucial to the determination of experimental protocols. In their paper “Importance of dosimetry...
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