Binding of the apolipoprotein E (ApoE)-containing lipoprotein complex to the low-density lipoprotein receptor (LDLR) is essential for cholesterol and lipid homeostasis. Inherited abnormalities in ApoE or LDLR function result in early onset cardiovascular disease and...
February 6th, 2019 – A leading dermatology center in Tennessee has commenced advanced skin radiotherapy treatments using the new RADiant treatment system from Xstrahl Medical, global leader in superficial radiotherapy devices to treat non-melanoma skin cancer and...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion...
In their study “Dosimetric characterization of a single crystal diamond detector in X-ray beams for preclinical research” Severin Kampfer, Nathan Cho Stephanie E. Combs, Jan J.Wilkens, investigated a single crystal diamond detector, the microDiamond detector from PTW,...
Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects...
January 31st, 2019 – Xstrahl Medical, global leader in superficial radiotherapy devices and advanced radiation research systems, has been named the best specialty radiotherapy systems manufacturer in the 2018 Global Health & Pharma Awards. Xstrahl manufactures...
OBJECTIVE Stereotactic body radiation therapy offers good lung local tumor control by the administration of a high dose per fraction in small volumes. Stereotactic body radiation therapy preclinical modeling is now possible, and our aim was to develop a model of focal...
The Xstrahl Small Animal Radiation Research Platform (SARRP) has been developed for conformal micro irradiation with on-board cone beam CT guidance. The graphics processing unit (GPU)-accelerated Superposition-Convolution (SC) method for dose computation has been...
OBJECTIVE The mechanical and geometric accuracy of small animal image‐guided radiotherapy (SA‐IGRT) systems is critical and is affected by a number of system‐related factors. Because of the small dimensions involved in preclinical radiotherapy research, such factors...
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