Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion...
In their study “Dosimetric characterization of a single crystal diamond detector in X-ray beams for preclinical research” Severin Kampfer, Nathan Cho Stephanie E. Combs, Jan J.Wilkens, investigated a single crystal diamond detector, the microDiamond detector from PTW,...
Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects...
January 31st, 2019 – Xstrahl Medical, global leader in superficial radiotherapy devices and advanced radiation research systems, has been named the best specialty radiotherapy systems manufacturer in the 2018 Global Health & Pharma Awards. Xstrahl manufactures...
OBJECTIVE Stereotactic body radiation therapy offers good lung local tumor control by the administration of a high dose per fraction in small volumes. Stereotactic body radiation therapy preclinical modeling is now possible, and our aim was to develop a model of focal...
The Xstrahl Small Animal Radiation Research Platform (SARRP) has been developed for conformal micro irradiation with on-board cone beam CT guidance. The graphics processing unit (GPU)-accelerated Superposition-Convolution (SC) method for dose computation has been...
OBJECTIVE The mechanical and geometric accuracy of small animal image‐guided radiotherapy (SA‐IGRT) systems is critical and is affected by a number of system‐related factors. Because of the small dimensions involved in preclinical radiotherapy research, such factors...
The precise dosimetric and geometric characteristics of small animal irradiators are essential to achieving reproducible dose delivery, especially in cases where image-guidance is utilized. Currently, radiochromic film is the established measurement tool used to...
In their study “Velocity-Based Adaptive Registration and Fusion for Fractionated Stereotactic Radiosurgery Using the Small Animal Radiation Research Platform” Paul J. Black, Deborah R. Smith, et al, implement a Velocity-based image fusion and adaptive deformable...
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