PURPOSE: We primarily determined whether the small animal radiation research platform could create a rat radiation cystitis model via targeted bladder irradiation (phase I). The response to treating early phase radiation cystitis in rats with transurethral catheter...
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Randomized multicenter follow-up trial on the effect of radiotherapy on painful heel spur (plantar fasciitis) comparing two fractionation schedules with uniform total dose: first results after three months’ follow-up
BACKGROUND: Our first trial on radiotherapy for painful heel spur published in 2012 comparing the analgesic effect of a standard dose (6 × 1.0Gy within three weeks) to that of a very low one (6 × 0.1Gy within three weeks) resulted in a highly significant superiority...
Identification of suitable endogenous controls for gene and miRNA expression studies in irradiated prostate cancer cells.
This study aimed to to evaluate the stability of commonly used endogenous control genes for messenger RNA (mRNA) (N = 16) and miRNAs (N = 3) expression studies in prostate cell lines following irradiation. The stability of endogenous control genes expression in irradiated (6 Gy) versus unirradiated controls was quantified using NormFinder and coefficient of variation analyses. HPRT1 and 18S were identified as most and least stable endogenous controls, respectively, for mRNA expression studies in irradiated prostate cells. SNORD48 and miR16 miRNA endogenous controls tested were associated with low coefficient of variations following irradiation (6 Gy). This study highlights that commonly used endogenous controls can be responsive to radiation and validation is required prior to gene/miRNAs expression studies.
H Lawlor, Armelle Meunier, Niamh McDermott, Thomas Lynch and Laure Marignol
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Acceptance, commissioning and clinical use of the WOmed T-200 kilovoltage X-ray therapy unit
OBJECTIVE: The objective of this work was to characterize the performance of the WOmed T-200-kilovoltage (kV) therapy machine. METHODS: Mechanical functionality, radiation leakage, alignment and interlocks were investigated. Half-value layers (HVLs) (first and second...
Xstrahl medical to showcase RADiant at UKRO, June 8th to 10th.
Xstrahl Medical (Booth 20) will introduce the exciting new Photoelectric Therapy system at the 8th UK Radiation Oncology (UKRO) Conference from the 8th to 10th of June at the Ricoh Arena, Coventry.
Xstrahl to showcase RADiant at DEGRO 2015 in Hamburg, Germany
Xstrahl will attend this year’s Deutschen Gesellschaft für Radioonkologie e.V. (DEGRO) in Hamburg, Germany from 25th – 28th June. There will be 4,000 attendees from around Europe looking to get the latest information and technology in the name of science.
Comprehensive quality assurance phantom for the small animal radiation research platform (SARRP)
PURPOSE: To develop and test the suitability and performance of a comprehensive quality assurance (QA) phantom for the Small Animal Radiation Research Platform (SARRP). METHODS AND MATERIALS: A QA phantom was developed for carrying out daily, monthly and annual QA...
Modeling a superficial radiotherapy X-ray source for relative dose calculations
The purpose of this study was to empirically characterize and validate a kilovoltage (kV) X-ray beam source model of a superficial X-ray unit for relative dose calculations in water and assess the accuracy of the British Journal of Radiology Supplement 25 (BJR 25)...
Semi-automatic cone beam CT segmentation of in vivo pre-clinical subcutaneous tumours provides an efficient non-invasive alternative for tumour volume measurements
OBJECTIVE: To evaluate the feasibility and accuracy of using cone beam CT (CBCT) scans obtained in radiation studies using the small-animal radiation research platform to perform semi-automatic tumour segmentation of pre-clinical tumour volumes. METHPOD: Volume...