Xstrahl Medical (Booth 6300) will introduce the next generation in 3rd party connectivity for Xstrahl systems at ESTRO35 in Turin, Italy on Saturday 30th April. XBridge offers Xstrahl users the ability to communicate with 3rd party clinical information systems, enabling data import of patient demographics and export of treatment information, ensuring traceability throughout a patient’s treatment.
Resources
Xstrahl Life Sciences at AACR 2016
What could you do with a SARRP? Take a look at some of the amazing research being presented at AACR 2016 with the help of this cutting edge equipment.
Xstrahl showcases the latest research being undertaken using SARRP and the range of Xstrahl Life Science products at ESTRO 2016
Xstrahl Life Sciences will be showcasing the recent developments for SARRP at ESTRO35 in Turin, Italy on Saturday 30th April. The Xstrahl booth (6300) will allow attendees to learn about how cancer research is being enhanced by the Xstrahl SARRP Image Guided Micro-Irradiator. A number of posters and presentations are being given at ESTRO35 that were developed with the help of Xstrahl Life Sciences products.
The effect of irradiation on tumor microenvironment and bone marrow cell migration in a pre-clinical tumor model.
To characterize the tumor microenvironment after standard radiation therapy (SRT) and pulsed radiation therapy (PRT) in Lewis lung carcinoma (LLC) allografts.
Jonathan L Kane, Sarah A Krueger, Alaa Hanna, Thomas R Raffel, George D Wilson, Gerard J Madlambayan and Brian Marples
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Some computer graphical user interfaces in radiation therapy
In this review, five graphical user interfaces (GUIs) used in radiation therapy practices and researches are introduced. They are: (1) the treatment time calculator, superficial X-ray treatment time calculator (SUPCALC) used in the superficial X-ray radiation therapy;...
Xstrahl Inc. to deliver its 50th SARRP to the University of California San Francisco
Xstrahl’s mission is to enable the most advanced radiation research, by producing clinically relevant research platforms. The Xstrahl SARRP research platform is an advanced irradiation device that allows researchers to refine cancer care. University of California San Francisco (UCSF) will take delivery of SARRP 50 in April and will join an ever growing SARRP community.
Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction.
Bladder drug delivery via catheter instillation is a widely used treatment for recurrence of superficial bladder cancer. Intravesical instillation of liposomal botulinum toxin has recently shown promise in the treatment of overactive bladder and interstitial cystitis/bladder pain syndrome, and studies of liposomal tacrolimus instillations show promise in the treatment of hemorrhagic cystitis. Liposomes are lipid vesicles composed of phospholipid bilayers surrounding an aqueous core that can encapsulate hydrophilic and hydrophobic drug molecules to be delivered to cells via endocytosis. This review will present new developments on instillations of liposomes and liposome-encapsulated drugs into the urinary bladder for treating lower urinary tract dysfunction.
Joseph J. Janicki, Michael B. Chancellor,* Jonathan Kaufman, Michele A. Gruber, and David D. Chancellor
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NF-kB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor supression.
Radiation modulates both tumor cells and immune cells in the tumor microenvironment to exert its anti-tumor activity; however, the molecular connection between tumor cells and immune cells that mediates radiation-exerted tumor suppression activity in the tumor microenvironment is largely unknown. We report here that radiation induces rapid activation of the p65/p50 and p50/p50 NF-κB complexes in human soft tissue sarcoma (STS) cells. Radiation-activated p65/p50 and p50/p50 bind to the TNFα promoter to activate its transcription in STS cells. Radiation-induced TNFα induces tumor cell death in an autocrine manner. A sublethal dose of Smac mimetic BV6 induces cIAP1 and cIAP2 degradation to increase tumor cell sensitivity to radiation-induced cell death in vitro and to enhance radiation-mediated suppression of STS xenografts in vivo. Inhibition of caspases, RIP1, or RIP3 blocks radiation/TNFα-induced cell death, whereas inhibition of RIP1 blocks TNFα-induced caspase activation, suggesting that caspases and RIP1 act sequentially to mediate the non-compensatory cell death pathways. Furthermore, we determined in a syngeneic sarcoma mouse model that radiation up-regulates IRF3, IFNβ, and the T cell chemokines CCL2 and CCL5 in the tumor microenvironment, which are associated with activation and increased infiltration of Th1/Tc1 T cells in the tumor microenvironment. Moreover, tumor-infiltrating T cells are in their active form since both the perforin and FasL pathways are activated in irradiated tumor tissues. Consequently, combined BV6 and radiation completely suppressed tumor growth in vivo. Therefore, radiation-induced NF-κB functions as a molecular link between tumor cells and immune cells in the tumor microenvironment for radiation-mediated tumor suppression.
Priscilla S. Simon, Kankana Bardhan, May R. Chen, Amy V. Paschall, Chunwan Lu, Roni J. Bollag, Feng-Chong Kong, JianYue Jin, Feng-Ming Kong, Jennifer L. Waller, Raphael E. Pollock and Kebin Liu
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Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice
Background & Aims The role of radiation therapy in the treatment of patients with pancreatic ductal adenocarcinoma (PDA) is controversial. Randomized controlled trials investigating the efficacy of radiation therapy in patients with locally advanced unresectable PDA...