BACKGROUND: Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. These small animal radiotherapy devices enable state-of-the-art image...
INTRODUCTION: Combined immune checkpoint blockade has led to rare autoimmune complications, such as fatal myocarditis. Recent approvals of several anti-programmed death 1 (anti-PD-1) drugs for lung cancer treatment prompted ongoing clinical trials that directly...
Xstrahl has received FDA clearance for the marketing of its latest skin cancer therapy device. RADiant System is a compact and ergonomic superficial X-Ray therapy system operating in the 10kV to 80kV range intended for superficial radiotherapy and surface electronic...
Xstrahl’s radiotherapy systems can be used to treat benign skin disorders, such as keloids, which usually demonstrate a high recurrence rate. To date, there has been no single, standardized modality agreed upon to produce the best results in the treatment of these...
The consequences of low to moderate doses of ionizing radiation (IR), especially for children exposed to CT scans, remains a challenging scientific topic. So far, no proper experimental models are available to better comprehend the consequences of exposure of the...
Non-melanoma skin cancers (NMSC) are the most commonly diagnosed cancers in the world. Despite their relatively low malignant potential and mortality rate, NMSC are associated with a high morbidity and substantial treatment cost, and they significantly affect patient...
Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor microenvironment (TME) are not fully elucidated. Although previous reports suggest an...
Neuroblastoma has one of the lowest survival rates of all childhood cancers despite the use of intensive treatment regimens usually consisting of a mix of surgery, chemotherapy, radiotherapy, stem cell transplant, immunotherapy and retinoid therapy. However, because...
Radiation therapy, traditionally used to successfully treat many internal cancers, can also provide highly effective—and often superior—therapy for skin cancers. Electron radiation therapy, which uses high-energy rays, is the choice for safe, effective skin cancer...
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