…imaging, identifying the target in space, being able to target a beam of radiation to a specific area, utilizing treatment planning software, being clinically translational, etc. and so on. But,…
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Radiation dose enhancement in skin therapy with nanoparticle addition: A Monte Carlo study on kilovoltage photon and megavoltage electron beams
…at the target layer with nanoparticle addition divided by the dose at the layer without nanoparticle addition, was calculated for each nanoparticle type, nanoparticle concentration and target layer thickness. RESULTS:…
Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma
Publication: Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma, 04 Jun 2020 Xstrahl System Utilized: SARRP Authors: Booyeon J. Han,Joseph D. Murphy,Shuyang Qin,Jian Ye,Taylor P….
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells
…in GSCs, which are reliant on RAD51-dependent DSB repair after radiation. RAD51 expression and RAD51 foci numbers fall when these cells move toward astrocytic differentiation. In GSCs, the small-molecule RAD51…
Xstrahl in Action: Radiation dose enhancement in skin therapy with nanoparticle addition
…tissue complication probabilities for organs-at-risk (OARs). Under such circumstances, nanoparticle-enhanced radiotherapy is suggested for providing dose enhancement in the target. Xiao J Zheng and James C L Chow in their…
Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy
…following radiation therapy. Ligation of Mertk on macrophages results in anti-inflammatory cytokine responses via NF-kB p50 upregulation, which in turn limits tumor control following radiation therapy. We demonstrate that in…
Use of Protoporphyrin Fluorescence to Determine Clinical Target Volume for Non-melanotic Skin Cancers Treated with Primary Radiotherapy
…extent of subclinical disease for poorly demarcated tumors treated with radiotherapy. MATERIALS AND METHODS: For 33 patients, PpIX photo-delineation was used to determine the clinical target volume (CTV2), which was…
Dose Painting with a Variable Collimator with the Small Animal Radiation Research Platform (SARRP).
…best approximates the target, thereby reducing the amount of dose absorbed in critical regions outside the target area. While multi-leaf collimators are common in human clinical systems, small animal radiotherapy…
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