We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Electronic brachytherapy and superficial radiation therapy are excellent treatment options for patients with basal cell or squamous cell carcinomas
DermRay helps dermatology practices leverage the benefits of Xstrahl’s dual modality Radiant system to expand treatment options for NMSC. For more than a decade, radiation oncologists Ankit Agarwal, MD and David Greene, MD, at DermRay have been providing turnkey...