We proposed to exploit hypoxia-inducible factor (HIF)-1alpha overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1alpha to arrangements of hypoxia response elements. CD is a prodrug activation enzyme, which converts inactive 5-fluorocytosine to active 5-fluorouracil (5-FU), allowing selective killing of vector containing cells.
Laure Marignol, Ruth Foley, Thomas Southgate, Mary Coffey, Donal Hollywood and Mark Lawler
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Xstrahl to Attend VCS and ASDS Conferences in Orlando
Xstrahl to Attend VCS and ASDS Conferences in Orlando: The recent hurricanes have affected so many, and the team at Xstrahl hopes that you and your family are safe. Our hearts go out to everyone as they face this difficult time ahead. Prior to the hurricanes, Xstrahl committed to attending two conferences in Orlando, FL this week, and organizers of the conferences have confirmed that they will still be happening. If you are attending either conference in Orlando, please visit our team to say hello. We’d love to meet you.
