Tumor hypoxia is a common feature of prostate tumors associated with the stabilization of hypoxia-inducible-factor 1alpha (HIF-1α) and poor prognosis following radiation therapy. Lack of oxygen at the time of irradiation is associated with radioresistance, but recent reports suggest radioresponse is also modulated by the dynamic nature of tumor hypoxia.
Derek Hennessey, Lynn Martin, Anne Atzberger, Thomas Lynch, Donal Hollywood and Laure Marignol
Download Paper
On the Other Side of the Machine
I have spent more than twenty years in radiation therapy, building systems, advising clinicians, and working to bring this technology to more patients. Last year, I became one of those patients myself. Diagnosed with Dupuytren’s contracture, I went through two rounds of low-dose radiation treatment at the same kind of facility I have spent my career supplying. What followed was one of the most clarifying professional experiences of my life, and a reminder that the gap between understanding a treatment and actually receiving one is wider than most people inside this industry ever appreciate.
