Life Sciences
Small Animal Radiation Research Platform
  • Small Animal Radiation Research Platform Small Animal Radiation Research Platform

Small Animal Radiation Research Platform (SARRP)

SARRP enhances the understanding of how radiation interacts with tissue, the mechanisms of DNA repair and ultimately how radiation can be used in the most effective way to improve patient centred healthcare.

SARRP incorporates CT imaging with precise radiation delivery to enable researchers to pinpoint an exact anatomical target and confidently deliver 0.5 mm beams to that point. This small animal irradiator can then deliver single or multiple beams of radiation to the target with the upmost accuracy, matching the clinical techniques used in oncology departments around the world.

Commercially available, Xstrahl’s research platform is transforming our understanding of the molecular biology of cancer. Radiation therapy is a treatment that is employed by over 50% of cancer patients worldwide, as well as providing the most advanced preclinical platform for validating the efficacy of novel radiation techniques and potential radiosensitizers for the treatment of cancer. The SARRP research platform has been designed to close the gap between current clinical techniques and our understanding of radiation biology/radiotherapy by enabling researchers to confidently assess the efficacy and efficiency of current treatment regimens and provide new data to the medical community that can help to shape the future of radiation protocols and concurrent therapies.

Click "Contact Us" below to understand more from our technical team how SARRP can be tailored specifically for your needs.

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Research Applications

The SARRP research platform enables researchers to replicate the radiotherapy process of imaging, target localization and radiotherapy treatment delivery techniques employed when treating patients in clinical oncology departments. In order to improve the efficiency of radiation therapy and minimize the short and long term side effects of cancer treatment it is vital to study radiation biology using in vivo models.

  • Radiobiology
  • Pre-clinical studies
  • DNA damage response
  • Tumour biology and the micro-environment
  • Bystander effects
  • Radiosensitizers
  • Cardiovascular toxicity
  • Oncology research
    • Preclinical validation of radiotherapy – assessing the risks of radiation exposure are balanced against the efficacy of the treatment in controlling and eliminating tumours
    • Characterize tumours that may not respond to ionizing radiation
    • DNA damage response
    • Can couple spatially targeted radiotherapy with molecularly targeted therapies to optimize treatments for solid tumours
    • Mechanism of tumour control
Advantages of the SARRP system

Advantages of the SARRP Platform:

  • Provides state-of-the-art 3D volumetric image guidance for localization and targeting of the dose
  • Conformal dose minimizes exposure to non-targeted tissues and organs
  • Non-invasive procedure
  • Easy to use, reliable, and reproducible
  • Customizable to meet new and innovative applications
  • High resolution, low imaging dose, on board CT imaging and 3D reconstruction
  • Image fusion options for easy target localization and avoidance of organs at risk
  • High precision beam geometry to achieve conformal dose distributions
  • Open platform to enable the addition of other imaging modalities for future research

The SARRP research platform has a flexibility of design that will meet any initial specification, and allows individual user groups to add on supporting imaging technologies to meet their future research needs—enabling continual system adaptation to facilitate the development of new and innovative applications. The repositionable product frame and automatically rotatable specimen stage allow radiation to be delivered at multiple angles without the need to reposition the specimen between exposures.

The SARRP research platform has been designed to match the range of movements available on clinical radiation therapy machines, enabling complex beam arrangements to be delivered for multiple directions without comprising the accuracy or reproducibility of the research protocol. The treatment planning module enables researchers to replicate clinical techniques easily and validate the dose distribution before delivering the radiation exposure. The key to matching clinical work is the ability to achieve conformal reproducible dose distributions, the SARRP platforms accuracy and planning system is a simple to use interface that provides a clinical solution to researchers.

Device Specification
External Dimensions W-148 cm, D-104 cm, H-205 cm
Total Weight Shielded Cabinet: 2540 kg
Total Weight Unshielded Cabinet: 454 kg
Treatment distances 30-38cm or 80cm FSD
Maximum Field Size 18 cm circle at 35 cm FSD
Tube Voltage 20-220 kV
Tube Current 0-25 mA
Maximum Power Output 3 kW



 

 

 

  

 

 

 

  • Mobile Built on wheels for simple transport
  • Robotic Stage X, Y, Z and θ with submillimetric movements
  • Imaging Modalities CBCT and Portal Imaging
  • Collimation Stereotactic Collimators and Variable Jaws
  • Control Interface Operates Motors and X-rays
  • Isocenter accuracy to 0.25 mm
  • On board cone beam CT and image reconstruction
  • Minimum field size of 0.5 mm diameter
  • Gantry and robotic specimen stage enable non-coplanar field arrangements

In addition, Xstrahl offers a range of stand alone X-Ray cabinets for more general lab-based irradiation techniques
Optional Features:

  • Dose Planning System including Image Fusion, Contouring, DVH, Fast Computation Times
  • Dose Commissioning System
Xstrahl SARRP Team
  • Xstrahl employ a team of individuals to support our SARRP users. The machine can be commissioned by our in house physicists. User training is done by our clinically trained staff who have both dosimetry and radiotherapy backgrounds. Therefore our staff can support and assist you in getting going with your experiments.
  • Behind them is our team of mechanical software and electronic designers all of whom strive to make your research goals a reality.
  • The SARRP consortium meets twice per year and allows all the users to gather and discuss their research find new collaborations. These meetings are timed around large conferences and also use the latest online technology to allow geographical boundaries to be eliminated.
  • SARRP forum – As requested by the consortium we have recently implemented an online discussion forum for users to exchange ideas.
  • Xstrahl engineers are based out of Atlanta and the UK, they can be on site to solve any issues the next day.
  • In-house experts are always available to assist with your research questions.
  • Xstrahl have collaborations with many universities in the UK, Europe and Asia we have a budget each year to support innovative research projects.
Publications

There has been over 70 articles published with the help of SARRP. For the full 70+ list of articles please click here to be directed to our publication resource page.