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Xstrahl In Action: Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies

 In Life Sciences News


Minibeam radiation therapy (MBRT) is an innovative synchrotron radiotherapy technique able to shift the normal tissue complication probability curves to significantly higher doses. However, its exploration was hindered due to the limited and expensive beamtime at synchrotrons.

In the paper “Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies: a proof of concept” Y. Prezado, M. Dos Santos, W. Gonzalez, G. Jouvion, C. Guardiola, S. Heinrich, D. Labiod, M. Juchaux, L. Jourdain, C. Sebrie & F. Pouzoulet, the team developed a cost-effective equipment to perform systematic radiobiological studies in view of MBRT.

Tumor control for various tumor entities were addressed as well as studies to unravel the distinct biological mechanisms involved in normal and tumor tissues responses when applying MBRT. With that aim, a series of modifications of a small animal irradiator (SARRP) were performed to make it suitable for MBRT experiments. The brains of two groups of rats were then irradiated. Half of the animals received a standard irradiation, the other half, MBRT. The animals were followed-up for 6.5 months.

They observed substantial brain damage in the group receiving standard radiotherapy, in contrast to the MBRT group, where no significant lesions were observed. This work proves the feasibility of the transfer of MBRT outside synchrotron sources towards a small animal irradiator.