The first image-guided solution designed for pre-clinical particle research.
SARRP Beamline offers the first image-guided platform designed for beamline irradiation. Built on the robust and established SARRP platform, SARRP Beamline provides CT guidance and robotic alignment for small animal experiments.
This development fundamentally advances pre-clinical experiments in particle therapy because it enables you to perform research using your clinical set-up, directly on your pre-clinical model.
Advantages of the SARRP System
SARRP has revolutionized the way in which pre-clinical radiobiology research is conducted, and SARRP Beamline is no different.
- Enables image-guided experiments with your particle beamlines.
- Open, compact design with unique CT geometry means the SARRP is the only system that aligned directly to the beamline with 0.24mm accuracy.
- Calibration of the imaging space with the particle beam is achieved through prove techniques, pioneered by the first SARRP Beamline users.
- Once a cross calibration is achieved, SARRP will conduct CT imaging and interface with third-party proton planning systems, and position the animal at the particle isocenter.
- SARRP immobilization devices enable flexible positioning to easily rotate animals and deliver pinpoint radiation at any angle.
- On-rail system ensures easy transportability in and out of the particle beam to enable the beam to be used for other research goals.
Here Is The Evidence of SARRP Beamline In Action
Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Kim MM, Irmen P, Shoniyozov K, Verginadis II, Cengel KA, Koumenis C, Metz JM, Dong L, Diffenderfer ES. Phys Med Biol. 2019 Jul 4;64(13):135013. doi: 10.1088/1361-6560/ab20d9.
An image-guided precision proton radiation platform for preclinical in vivo research. Ford E, Emery R, Huff D, Narayanan M, Schwartz J, Cao N, Meyer J, Rengan R, Zeng J, Sandison G, Laramore G, Mayr N. Phys Med Biol. 2017 Jan 7;62(1):43-58. Epub 2016 Dec 14
With nearly 200 peer-reviewed papers featuring pre-clinical research carried out using SARRP, SARRP is also the first choice for researchers who want to validate the advantages of particle therapy clinical protocols.
Add Ons & Accessories
In order to drive the field of pre-clinical radiation biology forward, technology must keep pace with clinical advancements. At Xstrahl, we’re dedicated to developing new and cutting-edge technology that allow for more precise and dynamic experimental methods. These company values can be seen in the development of the motorized variable collimator, respiratory gating system, and MuriGlo. All of which can be easily integrated into SARRP in a “plug-and-play” function of use.
For more information about the SARRP Beamline download our brochure.
Prior to acquisition of the SARRP we were left with an obvious and significant void in our pre-clinical arsenal to investigate existing and novel cancer therapies. The technological similarity of the SARRP with the medical systems in our clinic and availability of ongoing technical support from Xstrahl were decisive factors. The SARRP forms an integral part of our translational research pipeline and will greatly expand the capacity, potential and quality of our cancer and radiation research.
We have found SARRP an extremely valuable resource for pre-clinical work in which we aim to mimic clinical treatment regimens as closely as possible. SARRP enables efficient, accurate and reproducible pre-clinical radiotherapy that is especially valuable for assessing drug-radiation combinations in realistic schedules. We have been very impressed by the user-friendly interface in MuriPlan, which is straightforward for users and can be interfaced with imaging modalities such as MRI and bioluminescence for optimised image-guided planning. SARRP has become central to our translational pipeline in radiation biology and comes with extremely good support and maintenance to take the stress out of running large pre-clinical experiments.
SARRP has really made a significant impact in our lab, the ability to accurately target small volumes with image guidance hasn’t been possible before and we are now constantly evolving our approaches to leverage the technology to its maximum potential. Clearly our ability to delivery clinically relevant radiotherapy treatments in preclinical models has taken a major step forward, it up to us as a research community to translate this to the next generation of clinical innovatives
The irradiation devices developed by Xstrahl for radiobiological research, both in vitro and in vivo, certainly are of outstanding quality in this field of research. We use the Xstrahl SARRP system successfully for our in-vivo-research on orthotopic small animal tumour models. With this system we are able to mimic the clinical situation and especially irradiation in mice much more precisely and easier than in former times. So it helps us to make our research more reliable and more clinically relevant. From my point of view, the customer service provided by Xstrahl is close to perfect. All in all, the possibilities provided by Xstrahl's irradiation equipment, e.g to closely mimic the radiotherapeutic clinical routine in small animal models (CT-based treatment planning with the SARRP system) is absolutely outstanding.
We have been using the CIX2 X-ray cabinet for some years for cell culture experiments, and it is one of the most frequently used machines in our lab. In my opinion, the x-ray irradiator is a great tool for the irradiation of cells in our research lab. The cabinet runs very stable and is easy to operate (even for non-experienced visitors) and offers all options needed for our research making it extremely user-friendly. The possibility to change the filters quickly and to work with different distances away from the x-ray tube markedly enlarges the spectrum of experiments, which can be performed, and the safety aspect is hereby a big advantage. Furthermore, the technical support of X-Strahl is an outstanding example of good customer service.