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Imaging

Imaging is used in many different ways. Here we focus on imaging as an evaluation of disease and treatment of the disease.

Visualize Anatomy

Many different imaging devices are used in Radiation Oncology: Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography, Ultrasound, Bioluminescence and more.  SARRP can use these images in fusion to evaluate the area of interest.  The planning system offers multiple fusion tools.

The SARRP is an Image-Guided Microirradiator.  The image guidance is given through the use of CBCT.  CBCT allows the researcher to visualize anatomy with good spatial resolution in a 3 dimensional format.  Using these images the researcher directs radiation directly to the intended area while avoiding areas of risk.

CBCT

Positron Emission Tomography (PET) is a frequently used imaging technique for cancer patients.

Using positron-emitting radionuclides, functional areas can be viewed three dimensionally. This is typically used with a CT scanner to attach anatomical areas to the functional images. These images are able to target primary and metastatic disease that may not be seen on CT. It can be used in pre-clinical studies to mimic clinical practices.

Related articles

These researchers attempted to use SARRP to mimic a clinical treatment. They used a head and neck human tumor in a nude mouse model. They imaged these mice on a PET and created a plan based on the area of interest and a boost to the area of high FDG uptake. This PET image was fused with SARRP CT image while the mouse was anesthetized. 10Gy was given using a 15mm collimator to the whole tumor. The boost was treated with 10Gy using a non-coplanar dynamic arc with the 5mm collimator. The researchers found that a PET/CT with the SARRP can allow for pre-clinical validation of PET image-guided dose escalation IMRT treatments.

Find out more about the SARRP System.

MRI

The SARRP is an Image-Guided Microirradiator.

The image guidance is given through the use of CBCT. CBCT allows the researcher to visualize anatomy with good spatial resolution in a 3 dimensional format. Using these images the researcher directs radiation directly to the intended area while avoiding areas of risk.

Related Articles

These researchers are interested in finding a method to evaluate the location and quantification of Gold Nanoparticles (GNPs). A volume of 100uL of 50nm polymer coated GNPs were sealed in clinical bolus. They evaluated different concentrations of the GNPs: 0, 2.5, 3, 4, 5 and 10 mg/mL. These were implanted in the abdomen between the liver and the stomach in mice models. Utilizing the SARRP, the researchers took 5 CBCT images for each concentration. They measured the image intensity in the Axial, Sagittal and Coronal views. They created a ratio of the image intensity at 60kV and 0.8mA versus the gathered values from the GNPs . Significant image contrast was found for concentrations of 4 mg/mL and up. They would like to further this study in a tumor volume in a mouse model.

To understand more about the SARRP System contact our technical team.

Optical

In pre-clinical studies, researchers are interested in using as many tools as they can to for visualization, functional and molecular studies.

Optical imaging is a cost-effective and highly capable tool. Optical imaging is used in drug and treatment studies. In this instance, researchers can register optical images to SARRP CBCT images for better soft tissue targeting or to determine functional parts of the body to target.

Related Articles

These researchers were evaluating BLI guided irradiation for sparing of normal tissues, and quantitative and noninvasive longitudinal assessment of treatment response. BLI images of a flank pancreas mouse model was fused to SARRP CBCT images and used for setup and treatment planning of irradiation. This resulted in significant tumor growth delay for 20 days compared to the control. BLI/CBCT tumor estimations correlated well to PET/CT and necropsy specimen. ɣ-H2AX stain revealed that the BLI/CBCT guided irradiation spared surrounding normal tissues. The researchers successfully applied the SARRP to a bioluminescent, orthotopic preclinical pancreas cancer model to noninvasively: 1) allow the identification of tumor burden before therapy, 2) facilitate image-guided focal radiation therapy, and 3) allow normalization of tumor burden and longitudinal assessment of treatment response.

To better understand SARRP’s optical imaging capabilities and to find out more about the SARRP System in general.

Pet

Positron Emission Tomography (PET) is a frequently used imaging technique for cancer patients.

Using positron-emitting radionuclides, functional areas can be viewed three dimensionally. This is typically used with a CT scanner to attach anatomical areas to the functional images. These images are able to target primary and metastatic disease that may not be seen on CT. It can be used in pre-clinical studies to mimic clinical practices.

Related articles

These researchers attempted to use SARRP to mimic a clinical treatment. They used a head and neck human tumor in a nude mouse model. They imaged these mice on a PET and created a plan based on the area of interest and a boost to the area of high FDG uptake. This PET image was fused with SARRP CT image while the mouse was anesthetized. 10Gy was given using a 15mm collimator to the whole tumor. The boost was treated with 10Gy using a non-coplanar dynamic arc with the 5mm collimator. The researchers found that a PET/CT with the SARRP can allow for pre-clinical validation of PET image-guided dose escalation IMRT treatments.

Find out more about the SARRP System.

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