Pre-clinical research technology must keep pace with clinical advancements to continue to generate translational data. At Xstrahl, we continue to develop additional technologies which seamlessly integrate into the SARRP to mimic clinical radiation practice. Through active collaboration with academic institutions, in house experts, and SARRP user feedback. We strive to develop new and translational equipment which enables investigators to move the field of radiation science forward.
Contact us to understand more from our technical team how SARRP can be tailored specifically for your needs.
The Motorized Variable Collimator (MVC) is first of its kind in preclinical irradiation and unique to SARRP. The MVC is comprised of two symmetrical jaws with divergent edges. This design minimizes penumbra, resulting in minimal dose delivered outside of the radiation field. The dynamic jaws allow the user to dictate field size ranging from 1mm x 1mm, up to 40mm x 80mm. This ability enables the user to quickly adapt the system to perform large field irradiations (whole body), to small focal irradiation, such as brain metastases. The collimator is equipped with a light field which allows for increased workflow allowing the user to verify the irradiation field size, and location.
Complete autonomous control of the MVC is achieved through the fully integrated Muriplan treatment planning software.
In Radiation Therapy, there are several organs that move with respiration. This makes targeting just the moving tumor with radiation difficult. To compensate, a plan is created to encompass the entire movement area. Since a lot of normal tissue is also irradiated this treatment type is not optimal.
Gating allows a user to plan the treatment with the respiratory cycle. A fiberoptic cable records the pattern of chest movement and correlates it to the movement inside the chest. A shutter will open during the part of the respiratory cycle that is chosen for treatment thereby minimizing normal tissue damage.
As with clinical treatments, the need for innovative immobilization devices has expanded with the precision of the delivery systems. SARRP comes standard with a wide range of animal beds that enable researchers to achieve their experimental goals. Xstrahl are constantly adding to the range of animal immobilization systems to ensure accurate dose delivery to animals. Xstrahl develops custom immobilization devices to fit your specific research needs. Our in-house team of designers will work within your requirements to produce a device that is optimal for your research needs.
Available immobilization devices include:
All immobilization devices can be equipped with a heating modality to maintain body temperature while under anesthesia
Xstrahl has single or multiple animal anesthesia units available. These are CBCT/MRI compatible, and have built-in scavenging. Nose cones are provided with the system for more precise anesthesia dosage and scavenging. Anesthesia/gas scavenging is a common requirement of most IACUC protocols that utilize gas anesthesia.
SARRP has really made a significant impact in our lab, the ability to accurately target small volumes with image guidance hasn’t been possible before and we are now constantly evolving our approaches to leverage the technology to its maximum potential. Clearly our ability to delivery clinically relevant radiotherapy treatments in preclinical models has taken a major step forward, it up to us as a research community to translate this to the next generation of clinical innovatives
Prior to acquisition of the SARRP we were left with an obvious and significant void in our pre-clinical arsenal to investigate existing and novel cancer therapies. The technological similarity of the SARRP with the medical systems in our clinic and availability of ongoing technical support from Xstrahl were decisive factors. The SARRP forms an integral part of our translational research pipeline and will greatly expand the capacity, potential and quality of our cancer and radiation research.
We have found SARRP an extremely valuable resource for pre-clinical work in which we aim to mimic clinical treatment regimens as closely as possible. SARRP enables efficient, accurate and reproducible pre-clinical radiotherapy that is especially valuable for assessing drug-radiation combinations in realistic schedules. We have been very impressed by the user-friendly interface in MuriPlan, which is straightforward for users and can be interfaced with imaging modalities such as MRI and bioluminescence for optimised image-guided planning. SARRP has become central to our translational pipeline in radiation biology and comes with extremely good support and maintenance to take the stress out of running large pre-clinical experiments.
The irradiation devices developed by Xstrahl for radiobiological research, both in vitro and in vivo, certainly are of outstanding quality in this field of research. We use the Xstrahl SARRP system successfully for our in-vivo-research on orthotopic small animal tumour models. With this system we are able to mimic the clinical situation and especially irradiation in mice much more precisely and easier than in former times. So it helps us to make our research more reliable and more clinically relevant. From my point of view, the customer service provided by Xstrahl is close to perfect. All in all, the possibilities provided by Xstrahl's irradiation equipment, e.g to closely mimic the radiotherapeutic clinical routine in small animal models (CT-based treatment planning with the SARRP system) is absolutely outstanding.
We have been using the CIX2 X-ray cabinet for some years for cell culture experiments, and it is one of the most frequently used machines in our lab. In my opinion, the x-ray irradiator is a great tool for the irradiation of cells in our research lab. The cabinet runs very stable and is easy to operate (even for non-experienced visitors) and offers all options needed for our research making it extremely user-friendly. The possibility to change the filters quickly and to work with different distances away from the x-ray tube markedly enlarges the spectrum of experiments, which can be performed, and the safety aspect is hereby a big advantage. Furthermore, the technical support of X-Strahl is an outstanding example of good customer service.