Pre-clinical research technology must keep pace with clinical advancements to continue to generate translational data. At Xstrahl, we continue to develop additional technologies which seamlessly integrate into the SARRP to mimic clinical radiation practice. Through active collaboration with academic institutions, in house experts, and SARRP user feedback. We strive to develop new and translational equipment which enables investigators to move the field of radiation science forward.
Contact us to understand more from our technical team how SARRP can be tailored specifically for your needs.
The Motorized Variable Collimator (MVC) is first of its kind in preclinical irradiation and unique to SARRP. The MVC is comprised of two symmetrical jaws with divergent edges. This design minimizes penumbra, resulting in minimal dose delivered outside of the radiation field. The dynamic jaws allow the user to dictate field size ranging from 1mm x 1mm, up to 40mm x 80mm. This ability enables the user to quickly adapt the system to perform large field irradiations (whole body), to small focal irradiation, such as brain metastases. The collimator is equipped with a light field which allows for increased workflow allowing the user to verify the irradiation field size, and location.
Complete autonomous control of the MVC is achieved through the fully integrated Muriplan treatment planning software.
In addition to the standard set of collimators, Xstrahl can provide additional custom collimators to fit specific research needs. Often with larger animals (rats and rabbits), the standard stereotactic collimators provided with SARRP are not large enough. To accommodate for this, Xstrahl produces larger static collimators that provide 10cm of clearance from the isocenter. Shorter collimators are also available for rabbit studies.
Along with the standard set of collimators, custom collimators can be commissioned by Xstrahl and integrated into Muriplan.
|Square Collimators||Circular Collimators|
|2 cm x 2 cm||1.5 cm|
|4 cm x 4 cm||2 cm|
|8 cm x 8 cm||2.5 cm|
|10 cm x 10 cm||3 cm|
Xstrahl have developed a unique dose planning, verification, and treatment delivery system; Muriplan. This intuitive system has been designed to enable researchers to both plan and execute experiments. This fully integrated software will guide the scientist through a step by step process allowing them to carry out the treatment plan in an easy and seamless fashion.
Muriplan has been designed to mimic clinical practice by allowing the investigator to view the 3D reconstructed cone beam-CT image, register/fuse other images like MR and PET/CT, and contour the target as well as surrounding tissue. Furthermore, the capability to save a treatment plan and access it at a later time allows for increased workflow in fractionated treatment schedules. Along with evaluation and validation tools which include isodose lines and the ability to create a dose volume histogram (DVH), Muriplan allows for the control of all hardware components of SARRP included X-ray delivery, imaging, and robotics.
MuriGlo is an advanced in vivo optical imaging system with bioluminescence (BLI), bioluminescence tomography (BLT1) and transillumination fluorescence imaging (TFI2) capabilities. The system uses the photon emission data acquired from three rotating mirrors and a state-of-the-art 3D reconstruction engine that uses the anatomic and optical priors derived by diffuse optical tomography (DOT) and cone-beam CT (CBCT) data to yield a 3D center of mass (COM) of the target. The COM is then automatically fused with the SARRP CBCT allowing for more accurate treatment planning and targeting for lesions that are hard to identify by CBCT alone. Through recognition of highly sensitive data points throughout the specimen, MuriGlo provides accurate and reproducible optical quantitation. The versatility of the system provides the user an unprecedented range of imaging wavelengths (i.e. 450nm-800nm).
Muriglo is designed to be used on board the SARRP image guided irradiator for accurate targeting of tumors and metastasis. The unique docking design allows MuriGlo to be integrated within the SARRP or used in a standalone benchtop configuration. This dynamic configuration will extend the imaging capabilities of your lab, and increase workflow when using the SARRP in tandem.
1. NCI funded Academic-Industrial Partnership between John Hopkins University and Xstrahl. 2. Work in progress.
As with clinical treatments, the need for innovative immobilization devices has expanded with the precision of the delivery systems. SARRP comes standard with a wide range of animal beds that enable researchers to achieve their experimental goals. Xstrahl are constantly adding to the range of animal immobilization systems to ensure accurate dose delivery to animals. Xstrahl develops custom immobilization devices to fit your specific research needs. Our in-house team of designers will work within your requirements to produce a device that is optimal for your research needs.
Available immobilization devices include:
All immobilization devices can be equipped with a heating modality to maintain body temperature while under anesthesia
Xstrahl offers a state of the art, compact, air pressurized anesthesia and scavenging system from Univentor. The unique system is designed to reduce variables contributing to the oxygen effect seen in irradiated animals, which can significantly affect survival curves. The system requires only pressurized air from a pump, instead of from oxygen tanks. This reduces the overall cost, and removes potential occupational dangers associated with the use of oxygen tanks. Because of this, the user is able to keep the mouse under the same anesthesia for the imaging and irradiation procedure. Overall, this will save on the amount of anesthesia used, and also reduce the amount of time a mouse is exposed to anesthesia.
Dose Commissioning is performed by Xstrahl Using AAPM Task Guide-61, Xstrahl factory commission the ordered collimators and inputs the data into your SARRP Dose Calculator and Muriplan©. This data will include beam geometry, output and depth dose checks.
This set comes with a custom commissioning jig for your SARRP collimators and a platform for holding solid water to acquire a dose output. The commissioning jig is used to define the PDD for each collimator. This jig is used with Gafchromic® film to enable measurements of the surface and depth profiles. This removable jig can be attached to the primary beam collimator.
Developed in collaboration with the world renowned Gray Institute, the SARRP 4D Gating system has been adapted and optimized to our research platform to provide the most precise lung irradiation available in small animal models. SARRP continues to mimic the clinic by providing a first of its kind in preclinical research. The SARRP 4D Gating System Attachment was originally created to account for the dynamic movement of the lung nodules during radiotherapy. The attachment is comprised of an ion chamber, a filter selector, and a rapid response gating system. It is compatible with both the variable collimators and micro collimators.
The MuriQA phantom is composed of four sections and five distinct parts. These various sections are used to assess uniformity and geometric accuracy, resolution, modulation transfer function (MTF) and reconstruction value quantitatively or linearity.
Overall the phantom is 75 mm with a 12 mm radius. A flat bottom is provided for stability when placed in bed.
We have been using the CIX2 X-ray cabinet for some years for cell culture experiments, and it is one of the most frequently used machines in our lab. In my opinion, the x-ray irradiator is a great tool for the irradiation of cells in our research lab. The cabinet runs very stable and is easy to operate (even for non-experienced visitors) and offers all options needed for our research making it extremely user-friendly. The possibility to change the filters quickly and to work with different distances away from the x-ray tube markedly enlarges the spectrum of experiments, which can be performed, and the safety aspect is hereby a big advantage. Furthermore, the technical support of X-Strahl is an outstanding example of good customer service.
SARRP has really made a significant impact in our lab, the ability to accurately target small volumes with image guidance hasn’t been possible before and we are now constantly evolving our approaches to leverage the technology to its maximum potential. Clearly our ability to delivery clinically relevant radiotherapy treatments in preclinical models has taken a major step forward, it up to us as a research community to translate this to the next generation of clinical innovatives
We have found SARRP an extremely valuable resource for pre-clinical work in which we aim to mimic clinical treatment regimens as closely as possible. SARRP enables efficient, accurate and reproducible pre-clinical radiotherapy that is especially valuable for assessing drug-radiation combinations in realistic schedules. We have been very impressed by the user-friendly interface in MuriPlan, which is straightforward for users and can be interfaced with imaging modalities such as MRI and bioluminescence for optimised image-guided planning. SARRP has become central to our translational pipeline in radiation biology and comes with extremely good support and maintenance to take the stress out of running large pre-clinical experiments.
Prior to acquisition of the SARRP we were left with an obvious and significant void in our pre-clinical arsenal to investigate existing and novel cancer therapies. The technological similarity of the SARRP with the medical systems in our clinic and availability of ongoing technical support from Xstrahl were decisive factors. The SARRP forms an integral part of our translational research pipeline and will greatly expand the capacity, potential and quality of our cancer and radiation research.
The irradiation devices developed by Xstrahl for radiobiological research, both in vitro and in vivo, certainly are of outstanding quality in this field of research. We use the Xstrahl SARRP system successfully for our in-vivo-research on orthotopic small animal tumour models. With this system we are able to mimic the clinical situation and especially irradiation in mice much more precisely and easier than in former times. So it helps us to make our research more reliable and more clinically relevant. From my point of view, the customer service provided by Xstrahl is close to perfect. All in all, the possibilities provided by Xstrahl's irradiation equipment, e.g to closely mimic the radiotherapeutic clinical routine in small animal models (CT-based treatment planning with the SARRP system) is absolutely outstanding.