Xstrahl Life Sciences introduces new SARRP and Research Cabinet publications

 In Life Sciences News

Xstrahl Life Sciences have updated the pre clinical publication list to include the latest SARRP and Cabinet publications. The list of studies and papers highlight the amazing work that is being published with the help off Xstrahl Life Sciences systems. The following link will take you through to the Publication page,  where you can click on the links to view the relevant paper

Highlighted below are 3 of the most recent SARRP publications, each with a short description of the study/paper.

  1. Bioluminescence Tomography-Guided Radiation Therapy for Preclinical Research. Bin Zhang, PhD, Ken Kang-Hsin Wang, PhD, Jingjing Yu, PhD, Sohrab Eslami, PhD, Iulian Iordachita, PhD, Juvenal Reyes, MD, Reem Malek, PhD, Phuoc T. Tran, MD, PhD, Michael S. Patterson, PhD, and John W. Wong, PhD. Int J Radiat Oncol Biol Phys. April 2016. 1;94(5):1144-53. doi: 10.1016/j.ijrobp.2015.11.039. Epub 2015 Dec 14. Download Paper.The study details how Bioluminescence has enabled researchers to precisely visualize their tumors in vivo. BLI does not give insight to the depth of tumors which is essential for focal irradiation delivery and dose distribution. The study outlines the design and validation of a Bioluminescence Tomography system for targeting orthotopic tumors in vivo with the Xstrahl SARRP. The BLT images are fused with on board CBCT images for targeting. Validation of the targeting accuracy was completed in phantoms and in vivo. The CBCT/BLT targeting was able to differentiate multiple sources and accurately locate the Center of Mass of light sources. This system has been shown to successfully target orthotopic tumors with the SARRP which are difficult to distinguish with CBCT alone.
  2. A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies. Ethel J. Ngen , Lee Wang , Nishant Gandhi, Yoshinori Kato, Michael Armour, Wenlian Zhu, John Wong, Kathleen L. Gabrielson, Dmitri Artemov. Journal of Neuro-Oncology. June 2016, Volume 128, Issue 2, pp 225-233. Download Paper.Stem cell therapies are being developed for radiotherapy-induced brain injuries (RIBI). Magnetic resonance imaging (MRI) offers advantages for imaging transplanted stem cells. However, most MRI cell-tracking techniques employ superparamagnetic iron oxide particles (SPIOs), which are difficult to distinguish from haemorrhage. In current preclinical RIBI models, haemorrhage occurs concurrently with other injury markers. This makes the evaluation of the recruitment of transplanted SPIO-labelled stem cells to injury sites difficult. An RIBI model was developed, with early injury markers reflective of hippocampal dysfunction, which can be detected noninvasively with MRI and behavioural tests. Lesions were generated by sub-hemispheric irradiation of mouse hippocampi with single X-ray beams of 80 Gy. Lesion formation was monitored with anatomical and contrast-enhanced MRI and changes in memory and learning were assessed with fear-conditioning tests. Early injury markers were detected 2 weeks after irradiation. These included an increase in the permeability of the blood–brain barrier, demonstrated by a 92 ± 20 % contrast enhancement of the irradiated versus the non-irradiated brain hemispheres, within 15 min of the administration of an MRI contrast agent. A change in short-term memory was also detected, as demonstrated by a 40.88 ± 5.03 % decrease in the freezing time measured during the short-term memory context test at this time point, compared to that before irradiation. SPIO-labelled stem cells transplanted contralateral to the lesion migrated toward the lesion at this time point. No haemorrhage was detected up to 10 weeks after irradiation. This model can be used to evaluate SPIO-based stem cell-tracking agents, short-term.
  3. NF-kB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor supression. Priscilla S. Simon1,4,6, Kankana Bardhan1, May R. Chen1, Amy V. Paschall1,4,6, Chunwan Lu Roni J. Bollag Feng-Chong Kong JianYue Jin Feng-Ming Kong Jennifer L. Waller Raphael E. Pollock and Kebin Liu. OncoTarget. March 2016. DOI: 10.18632/oncotarget.8246 Download Paper.This paper explores the molecular mechanism behind radiation induced tumor suppression. With specific interest between tumor and immune cells. They evaluate TNFa, p65/p50, RIP1, RIP3, IRF3, IFNb, CCL2, CCL5, perforin, FasL.