SARRP Research Platform
Enables Image Guided Micro-Irradiation (IGMI™) techniques
In collaboration with leading researchers, Xstrahl has applied its extensive medical X-Ray knowledge to develop a powerful and customizable research platform known as SARRP. The research platform is based on state-of-the-art Image Guided Micro-Irradiation (IGMI™) techniques. The SARRP research platform incorporates CT imaging with precise radiation delivery to enable researchers to pinpoint an exact anatomical target and confidently deliver 0.5 mm beams to that point. The SARRP platform can then deliver single or multiple beams of radiation to the target with the upmost accuracy, matching the clinical techniques used in oncology departments around the world.
Commercially available, Xstrahl’s research platform is transforming our understanding of the molecular biology of cancer. Radiation therapy is a treatment that is employed by over 50% of cancer patients worldwide, as well as providing the most advanced preclinical platform for validating the efficacy of novel radiation techniques and potential radiosensitizers for the treatment of cancer. The SARRP research platform has been designed to close the gap between current clinical techniques and our understanding of radiation biology/radiotherapy by enabling researchers to confidently assess the efficacy and efficiency of current treatment regimes and provide new data to the medical community that can help to shape the future of radiation protocols and concurrent therapies.
The SARRP research platform has a flexibility of design that will meet any initial specification, and allows individual user groups to add on supporting imaging technologies to meet their future research needs—enabling continual system adaptation to facilitate the development of new and innovative applications.
The repositionable product frame and automatically rotatable specimen stage allow radiation to be delivered at multiple angles without the need to reposition the specimen between exposures.
The SARRP research platform has been designed to match the range of movements available on clinical radiation therapy machines, enabling complex beam arrangements to be delivered for multiple directions without comprising the accuracy or reproducibility of the research protocol. The treatment planning module enables researchers to replicate clinical techniques easily and validate the dose distribution before delivering the radiation exposure. The key to matching clinical work is the ability to achieve conformal reproducible dose distributions, the SARRP platforms accuracy and planning system is a simple to use interface that provides a clinical solution to researchers.
SARRP Research Platform Advantages
- Provides state-of-the-art 3D volumetric image guidance for localization and targeting of the dose
- Conformal dose minimizes exposure to non-targeted tissues and organs
- Non-invasive procedure
- Easy to use, reliable, and reproducible
- Customizable to meet new and innovative applications
- High resolution, low imaging dose, on board CT imaging and 3D reconstruction
- Image fusion options for easy target localization and avoidance of organs at risk
- High precision beam geometry to achieve conformal dose distributions
- Open platform to enable the addition of other imaging modalities for future research
SARRP System Features
- Isocenter accuracy to 0.25 mm
- On board cone beam CT and image reconstruction
- Minimum field size of 0.5 mm diameter
- Gantry and robotic specimen stage enable non-coplanar field arrangements
In addition, Xstrahl offers a range of stand alone X-Ray cabinets for more general lab-based irradiation techniques.
The SARRP research platform enables researchers to replicate the radiotherapy process of imaging, target localization and radiotherapy treatment delivery techniques employed when treating patients in clinical oncology departments. In order to improve the efficiency of radiation therapy and minimize the short and long term side effects of cancer treatment it is vital to study radiation biology using in vivo models.
- Pre clinical studies
- DNA damage response
- Tumour biology and the micro-environment
- Bystander effects
- Cardiovascular toxicity
- Oncology research
- Preclinical validation of radiotherapy – assessing the risks of radiation exposure are balanced against the efficacy of the treatment in controlling and eliminating tumours
- Characterize tumours that may not respond to ionizing radiation
- DNA damage response
- Can couple spatially targeted radiotherapy with molecularly targeted therapies to optimize treatments for solid tumours
- Mechanism of tumour control
- Normal tissue injury by radiotherapy
- Immunology disease
- Cardiovascular diseases
- Radiobiological effectiveness