Cabinet irradiators have been used for years in pre-clinical research. They offer quick setup and multiple mice can be treated at the same time. Unlike human machines there is no collimation to the beam. This allows many organs at risk to be fully dosed. This keeps the researcher from achieving clinically relevant doses.
This study focuses around a Cabinet Irradiator (220kV 17mA), the Standford MicroIrradiator (120kV 50mA) and the SARRP Platform (225kV 13mA). Each system was modeled in Monte Carlo for comparison of 2 different planning techniques. The first setup was using a single large beam for a subcutaneous model. The Cabinet Irradiator and SARRP gave overall homogeneous dose distributions. The Stanford Irradiator was a bit more heterogeneous due to the kV and mA used.
For an orthotopic model, the Cabinet Irradiator gave the same field. The Stanford MicroIrradiator and SARRP used a 9 beam arrangement. The multi-beam conformal methods showed superior organ at risk sparing. The Stanford MicroIrradiator again showed a more heterogeneous dose distribution across the animal due to the lower energy. SARRP was shown to deliver a homogenous dose distribution as well as a faster beam on time (2.7 minutes vs. 3.8 minutes on the Stanford MicroIrradiator).
Use of an Image Guided MicroIrradiator such as SARRP allows the user to generate a CBCT, place an isocenter, create a plan and deliver dose directly to the intended area. To find out more about the SARRP Platform click here.