In pre-clinical studies, researchers are interested in using as many tools as they can to for visualization, functional and molecular studies. Optical imaging is a cost-effective and highly capable tool. Optical imaging is used in drug and treatment studies. In this instance, researchers can register optical images to SARRP CBCT images for better soft tissue targeting or to determine functional parts of the body to target.
These researchers were evaluating BLI guided irradiation for sparing of normal tissues, and quantitative and noninvasive longitudinal assessment of treatment response. BLI images of a flank pancreas mouse model was fused to SARRP CBCT images and used for setup and treatment planning of irradiation. This resulted in significant tumor growth delay for 20 days compared to the control. BLI/CBCT tumor estimations correlated well to PET/CT and necropsy specimen. ɣ-H2AX stain revealed that the BLI/CBCT guided irradiation spared surrounding normal tissues. The researchers successfully applied the SARRP to a bioluminescent, orthotopic preclinical pancreas cancer model to noninvasively: 1) allow the identification of tumor burden before therapy, 2) facilitate image-guided focal radiation therapy, and 3) allow normalization of tumor burden and longitudinal assessment of treatment response.
To better understand SARRP's optical imaging capaabilities and to find out more about the SARRP Platform in general click here.