Life Sciences
Imaging

Imaging

Many different imaging devices are used in Radiation Oncology: Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography, Ultrasound, Bioluminescence and more.  SARRP can use these images in fusion to evaluate the area of interest.  The planning system offers multiple fusion tools.

The SARRP is an Image-Guided Microirradiator.  The image guidance is given through the use of CBCT.  CBCT allows the researcher to visualize anatomy with good spatial resolution in a 3 dimensional format.  Using these images the researcher directs radiation directly to the intended area while avoiding areas of risk. 

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CBCT

The SARRP is an Image-Guided Microirradiator. The image guidance is given through the use of CBCT. CBCT allows the researcher to visualize anatomy with good spatial resolution in a 3 dimensional format. Using these images the researcher directs radiation directly to the intended area while avoiding areas of risk.

 

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These researchers are interested in finding a method to evaluate the location and quantification of Gold Nanoparticles (GNPs). A volume of 100uL of 50nm polymer coated GNPs were sealed in clinical bolus. They evaluated different concentrations of the GNPs: 0, 2.5, 3, 4, 5 and 10 mg/mL. These were implanted in the abdomen between the liver and the stomach in mice models. Utilizing the SARRP, the researchers took 5 CBCT images for each concentration. They measured the image intensity in the Axial, Sagittal and Coronal views. They created a ratio of the image intensity at 60kV and 0.8mA versus the gathered values from the GNPs . Significant image contrast was found for concentrations of 4 mg/mL and up. They would like to further this study in a tumor volume in a mouse model.

 

Research Platform 

To find out more about the SARRP Platform click here.

MRI

Magnetic Resonance Imaging offers better soft tissue differentiation than the CBCT imaging offered on SARRP. Due to its poor spatial resolution, it is not used for planning. SARRP offers fusion software to add the MRI to the CBCT coordinate system. This allows the user to better visualize certain structures to define targets to treat.

 

Related Articles

  • WMIC 2013 P358

These researchers are proposing that research using radiation moves from single beams to a multi-beam approach as used clinically. Using a F98 glioblastoma therapeutic rat model they imaged first in magnetic resonance imaging (MRI) and used this to define the tumor from the normal brain tissue. They fused this image to a CBCT image created on the SARRP and localized the tumor area. A plan was created as a 3D-conformal arc RT with the Small Animal Radiation Research Platform (SARRP). Three non-coplanar beams using a 3mm x3mm collimator delivered 20 Gy. The results confirm the applicability of this method as a valuable model for combined radiation and chemotherapy of glioblastoma in rats similar to the approach in the clinic.

 

Research Platform

To find out more about the SARRP Platform click here.

Optical

In pre-clinical studies, researchers are interested in using as many tools as they can to for visualization, functional and molecular studies. Optical imaging is a cost-effective and highly capable tool. Optical imaging is used in drug and treatment studies. In this instance, researchers can register optical images to SARRP CBCT images for better soft tissue targeting or to determine functional parts of the body to target.

 

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These researchers were evaluating BLI guided irradiation for sparing of normal tissues, and quantitative and noninvasive longitudinal assessment of treatment response. BLI images of a flank pancreas mouse model was fused to SARRP CBCT images and used for setup and treatment planning of irradiation. This resulted in significant tumor growth delay for 20 days compared to the control. BLI/CBCT tumor estimations correlated well to PET/CT and necropsy specimen. ɣ-H2AX stain revealed that the BLI/CBCT guided irradiation spared surrounding normal tissues. The researchers successfully applied the SARRP to a bioluminescent, orthotopic preclinical pancreas cancer model to noninvasively: 1) allow the identification of tumor burden before therapy, 2) facilitate image-guided focal radiation therapy, and 3) allow normalization of tumor burden and longitudinal assessment of treatment response.

 

Research Platform 

To better understand SARRP's optical imaging capaabilities and to find out more about the SARRP Platform in general click here.

PET

Positron Emission Tomography (PET) is a frequently used imaging technique for cancer patients. Using positron-emitting radionuclides, functional areas can be viewed three dimensionally. This is typically used with a CT scanner to attach anatomical areas to the functional images. These images are able to target primary and metastatic disease that may not be seen on CT. It can be used in pre-clinical studies to mimic clinical practices.

 

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These researchers attempted to use SARRP to mimic a clinical treatment. They used a head and neck human tumor in a nude mouse model. They imaged these mice on a PET and created a plan based on the area of interest and a boost to the area of high FDG uptake. This PET image was fused with SARRP CT image while the mouse was anesthetized. 10Gy was given using a 15mm collimator to the whole tumor. The boost was treated with 10Gy using a non-coplanar dynamic arc with the 5mm collimator. The researchers found that a PET/CT with the SARRP can allow for pre-clinical validation of PET image-guided dose escalation IMRT treatments.

 

Research Platform 

To find out more about the SARRP Platform click here.